Welcome to the Yaron Lab
Biotherapeutics Engineering Lab
Principal Investigator
Jordan Yaron
Assistant Professor
School for Engineering of Matter, Transport and Energy
Yaron's research focuses on biomaterial-tissue interactions and investigation of novel therapeutics and platforms to enhance healing and repair in complex inflammatory conditions.
The problem
Complex Tissue Injury and Lack of Effective Repair
Injuries are a ubiquitous fact of life. However, despite multiple millions of new cases each year and several billions of dollars in annual health care costs, there are no effective treatments for many types of complex injuries, such as those in the skin and spinal cord.
Our approach
1. Development of novel biomaterial scaffolds
We engineer biomaterials with enhanced and expanded functionality to promote tissue repair and regeneration.
2. Controlled delivery of bioactives
We develop methods to delivery bioactives with the goal of treating tissues with “the right drug at the right time” in order to stimulate reparative pathways.
3. Identification and development of novel bioactive agents
We reverse engineer dysfunctional signaling observed in diseased states and pro-healing pathways stimulated by biomaterials to facilitate target identification for novel bioactives.
Lab news
Our work on the fundamental physiologic role for SerpinB3 in wound healing has been published in the Proceedings of the National Academy of Sciences. This work was a 5-year effort that began while Dr.
Dr. Yaron has received a 5-year Stephen I. Katz R01 to investigate novel disease mechanisms and therapeutic targets in psoriasis.