This project aims to build human-centric healthcare environments by integrating cyber innovations (advanced data analytics and supervisory control) with physical system innovations (sensors and sensor fusion) to develop a customizable and responsive healthcare environment which has the potential to reduce stress and improve quality of care on an individual scale. The proposed research integrates cyber and physical components at several levels: for example, physical sensors and sensor cyber data interpretation, and physical environmental attributes and their cyber-enabled control. Research outcomes are translational to other application domains where interaction between built environment and human physiology and performance is of interest, including education and other health care settings. The project includes multi-level validation by assessing stress reduction in virtual testbed, laboratory testbed, and also real time field studies at CHOP of a customizable responsive environmental control system.