{"id":48,"date":"2019-02-14T19:20:30","date_gmt":"2019-02-14T19:20:30","guid":{"rendered":"https:\/\/labs.engineering.asu.edu\/varman\/?page_id=48"},"modified":"2023-06-16T17:00:20","modified_gmt":"2023-06-16T17:00:20","slug":"welcome-to-the-synthetic-and-systems-biology-laboratory","status":"publish","type":"page","link":"https:\/\/labs.engineering.asu.edu\/varman\/","title":{"rendered":"Welcome to the Synthetic and Systems Biology Laboratory"},"content":{"rendered":"<div class=\"uds-hero-md alignfull has-btn-row \" style=\"margin-bottom:var(--wp--preset--spacing--uds-size-8);\"><div class=\"hero-overlay\"><\/div><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1244\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-scaled.jpg\" class=\"hero\" alt=\"\" srcset=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-scaled.jpg 2560w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-300x146.jpg 300w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-1024x498.jpg 1024w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-768x373.jpg 768w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-1536x747.jpg 1536w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/11\/20191203_132128-2048x996.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><div class=\"acf-innerblocks-container\">\n\n\n\n<h1 class=\"wp-block-heading has-white-color has-text-color\">Synthetic and Systems Biology Laboratory<\/h1>\n\n\n\n<div class=\"wp-block-group content is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"has-white-color has-text-color wp-block-paragraph\">Developing engineered microbial systems that are highly-efficient for the sustainable production of chemicals, fuels, and pharmaceuticals from renewable resources.<\/p>\n<\/div>\n\n<\/div><\/div>\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-930feb06 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<p class=\"is-style-lead wp-block-paragraph\">The overarching research goal of our laboratory is to develop engineered microbial systems that are highly-efficient for the sustainable production of chemicals, fuels, and pharmaceuticals from renewable resources. In our lab we harness the diversity in microbial metabolism for improved product synthesis by selecting the microbial hosts rationally depending on the substrate to be utilized and the product to be synthesized.&nbsp; <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition, we also utilize <sup>13<\/sup>C-Fingerprinting and <sup>13<\/sup>C-Metabolic flux analysis along with other omics techniques to decipher the metabolism of engineered bacterium, and thereby develop novel strategies to further improve the performance of the microbial strains.&nbsp; <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metabolic Engineering and Synthetic Biology research is interdisciplinary in nature, and involves the fundamentals and techniques derived from Chemical Engineering, Biochemistry, Microbiology, and Molecular Biology.&nbsp;<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<h2 class=\"wp-block-heading\"><span class=\"highlight-gold\">Research Topics<\/span><\/h2>\n\n\n\n<ol class=\"is-style-uds-steplist-gold wp-block-list\" style=\"margin-top:var(--wp--preset--spacing--uds-size-6)\">\n<li>Topic 1: Metabolic engineering&nbsp;of cyanobacteria for the production of fuels and chemicals. <\/li>\n\n\n\n<li>Topic 2:\nUtilizing synthetic biology for the translocation of proteins for breaking down\npolymers or protein production.<\/li>\n\n\n\n<li>Topic 3: <sup>13<\/sup>C-labeling technique for metabolic pathway analysis and flux analysis.<\/li>\n\n\n\n<li>Topic 4: Conversion\nof lignin derived aromatics into value-added chemicals and pharmaceuticals through\nsynthetic biology and metabolic engineering.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:6rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-blockgallery-carousel\"><div class=\"is-cropped blockgallery has-no-alignment has-caption-style-dark\"><div class=\"has-carousel has-carousel-xlrg\" style=\"height:444px\" data-flickity=\"{&quot;autoPlay&quot;:5000,&quot;draggable&quot;:true,&quot;pageDots&quot;:false,&quot;prevNextButtons&quot;:true,&quot;wrapAround&quot;:true,&quot;arrowShape&quot;:{&quot;x0&quot;:10,&quot;x1&quot;:60,&quot;y1&quot;:50,&quot;x2&quot;:65,&quot;y2&quot;:45,&quot;x3&quot;:20}}\"><div class=\"blockgallery--item\"><figure class=\"blockgallery--figure\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"300\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2019\/03\/biorefine.jpg\" alt=\"Biorefinery diagram. Biomass, methane, CO2 and organic wastes are processed by a biological &quot;factory&quot; and turned into commodity chemicals, biofuels, pharmaceuticals and flavors or fragrances.\" data-id=\"120\" data-link=\"https:\/\/live-varman-lab.pantheonsite.io\/biorefine\/\" class=\"wp-image-120\" srcset=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2019\/03\/biorefine.jpg 650w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2019\/03\/biorefine-300x138.jpg 300w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/figure><\/div><div class=\"blockgallery--item\"><figure class=\"blockgallery--figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"630\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2020\/01\/IMG_20200120_172305-2-1024x630.jpg\" alt=\"\" data-id=\"329\" data-link=\"https:\/\/live-varman-lab.pantheonsite.io\/welcome-to-the-synthetic-and-systems-biology-laboratory\/img_20200120_172305-2\/\" class=\"wp-image-329\" srcset=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2020\/01\/IMG_20200120_172305-2-1024x630.jpg 1024w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2020\/01\/IMG_20200120_172305-2-300x185.jpg 300w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2020\/01\/IMG_20200120_172305-2-768x472.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><div class=\"blockgallery--item\"><figure class=\"blockgallery--figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"788\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2019\/03\/chainreaction-1024x788.png\" alt=\"A chain reaction biology diagram\" data-id=\"74\" data-link=\"https:\/\/live-varman-lab.pantheonsite.io\/chainreaction\/\" class=\"wp-image-74\"\/><\/figure><\/div><div class=\"blockgallery--item\"><figure class=\"blockgallery--figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"461\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/1-ASU-Biodesign-C-022-1024x461.jpg\" alt=\"\" data-id=\"368\" data-link=\"https:\/\/live-varman-lab.pantheonsite.io\/welcome-to-the-synthetic-and-systems-biology-laboratory\/1-asu-biodesign-c-022\/\" class=\"wp-image-368\" srcset=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/1-ASU-Biodesign-C-022-1024x461.jpg 1024w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/1-ASU-Biodesign-C-022-300x135.jpg 300w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/1-ASU-Biodesign-C-022-768x346.jpg 768w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/1-ASU-Biodesign-C-022.jpg 1400w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><div class=\"blockgallery--item\"><figure class=\"blockgallery--figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"478\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/L22997-ASU-Biodesign-C_Hero-1500x700-1-1024x478.jpg\" alt=\"\" data-id=\"369\" data-link=\"https:\/\/live-varman-lab.pantheonsite.io\/welcome-to-the-synthetic-and-systems-biology-laboratory\/l22997-asu-biodesign-c_hero-1500x700\/\" class=\"wp-image-369\" srcset=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/L22997-ASU-Biodesign-C_Hero-1500x700-1-1024x478.jpg 1024w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/L22997-ASU-Biodesign-C_Hero-1500x700-1-300x140.jpg 300w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/L22997-ASU-Biodesign-C_Hero-1500x700-1-768x358.jpg 768w, https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2021\/02\/L22997-ASU-Biodesign-C_Hero-1500x700-1.jpg 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><div class=\"blockgallery--item\"><figure class=\"blockgallery--figure\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"693\" src=\"https:\/\/labs.engineering.asu.edu\/varman\/wp-content\/uploads\/sites\/137\/2019\/03\/dotline-diagram-1024x693.png\" alt=\"Dots and lines in a diagram. Probably boilogical research related. Or possibly a subway map of London. :-)\" data-id=\"75\" data-link=\"https:\/\/live-varman-lab.pantheonsite.io\/dotline-diagram\/\" class=\"wp-image-75\"\/><\/figure><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p class=\"mb-2\">The overarching research goal of our laboratory is to develop engineered microbial systems that are highly-efficient for the sustainable production of chemicals, fuels, and pharmaceuticals from renewable resources. In our lab we harness the diversity in microbial metabolism for improved product synthesis by selecting the microbial hosts rationally depending on the substrate to be utilized&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-48","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/pages\/48","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/comments?post=48"}],"version-history":[{"count":0,"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/pages\/48\/revisions"}],"wp:attachment":[{"href":"https:\/\/labs.engineering.asu.edu\/varman\/wp-json\/wp\/v2\/media?parent=48"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}