Metabolic programs are altered in neurodevelopmental disorders, including Autism and ADHD. We currently do not understand the metabolic requirements of human cortical cells in typical and disease-states. To explore the relationship between metabolism and cell fate decisions, we are using organoid and mouse brain transplantation models paired with genome editing tools, single cell transcriptomics, and real time assays to determine the metabolic programs used by diverse human cortical cell types over time.