Appropriate signaling mechanisms are required for typical neural development where alterations lead to cortical malformations. We are particularly interested in understanding the role of mTOR signaling and how changes in this pathway lead to co-morbid phenotypes including epilepsy, developmental delay, and Autism. To better understand the molecular etiology of these disorders, we use patient-derived induced pluripotent stem cell lines and gene editing techniques to explore the impact of molecular changes on cellular morphology, fate decisions, and cortical organization.